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KMID : 1123920130270010078
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 1 p.78 ~ p.82
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Inhibitory Effect of Scolopendra Morsitans L. Ether Extract on Lipopolysaccharide-Induced Inflammatory Response in RAW 264.7 Cells
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Jung Ho-Kyung
Cho Hyun-Woo
Jung Won-Seok
Choi In-Young
Cho Jung-Hee
Jung Su-Young
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Abstract
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It has been reported that Scolopendra morsitans L.(SML) has beneficial effects on human health and diverse diseases. The purpose of this study was to investigate the anti-inflammatory effects of ether extract from Scolopendra morsitans L. on lipopolysaccharide(LPS)-induced inflammatory response. Thus, we examined the inhibitory effect of SML ether fraction on LPS-induced increase of inflammatory mediators(NO, iNOS, COX-2, and IκBα) and pro-inflammatory cytokines(TNF-α) in RAW 264.7 cells. In the present study, SML ether extract itself decreased cell viability in a dose dependent manner(> 100 μg/ml). In addition, LPS increased NO production, iNOS expression and phosphorylation of Iκ-Bα, which were blocked by the treatment of SML ether fraction in a dose dependent manner. Furthermore, the treatment of LPS increased TNF-α production. However, the pretreatment of SML ether fraction prevented the LPS-induced TNF-α production in dose dependant manner. Taken together, our results suggest that SML may be a beneficial drug against inflammatory diseases such as sepsis.
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KEYWORD
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Scolopendra morsitans L., Anti-inflammation, Nitric oxide, COX-2, TNF-α
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